Difficulties in diagnosing kidney damage in chronic lymphocytic leukemia and indolent lymphomas

Mikhailova Z.D., Saidov A.D., Cherepanova V.V.

1) City Clinical Hospital No. 38, Nizhny Novgorod, Russia; 2) Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia

A search in MEDLINE/PubMed, EMBASE, Web of Science and Elibrary.ru databases using the keywords: paraneoplastic glomerulopathy, indolent lymphomas was conducted in order to study various variants of kidney damage in lymphoproliferative diseases (LPD). Kidney damage can be diagnosed at the onset of LPD or during its progression, relapse. At the same time, it is possible to verify the presence of LPD based on the results of a nephrobiopsy in the absence of a characteristic clinical picture of a hematological disease. The causes of kidney damage in oncohematological practice include specific lymphoid infiltration of the organ, aggravation of comorbid pathology, additional infection, paraneoplastic reactions, tumor lysis syndrome and toxic kidney damage by drugs with damage to the glomeruli, tubules or vessels of the kidneys.

Keywords

About the Authors

Zinaida D. Mikhailova – Dr.Sci. (Med.), Associate Professor, Consultant, City Clinical Hospital No. 38. Address: 22 Chernyshevsky st., Nizhny Novgorod, 603000;
Tel.: 8 (910) 392-08-15; E-mail: zinaida.mihailowa@yandex.ru. ORCID: https://orcid.org/0000-0002-0926-6038.
Aleksandr D. Saidov – Hematologist, City Clinical Hospital No. 38. Address: 22 Chernyshevsky st., Nizhny Novgorod, 603000; e-mail: best.doc38@yandex.ru.
ORCID: https://orcid.org/0000-0001-9602-6245.
Valentina V.Cherepanova – Dr.Sci. (Med.), Associate Professor; Professor at the Department of Internal Medicine, Institute of Therapy, Lobachevsky State University
of Nizhny Novgorod. Address: 23 Gagarin Ave., Nizhny Novgorod, 603065; e-mail: cherepanova.v@inbox.ru. ORCID: https://orcid.org/0000-0002-7730-3988.

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