Anemia in chronic kidney disease. Prevalence and relationship with renal function parameters

Murkamilov I.T., Aitbaev K.A., Fomin V.V., Raimzhanov Z.R., Khakimov Sh.Sh., Duysheeva G.K., Abdurakhmanov I.U., Solizhonov Zh.I., Boymurodov Y.R., Yusupova T.F., Yusupova Z.F., Yusupov F.A., Abdibaliev I.A., Gasanov K.A., Khabibullaev K.K., Ymankulov D.S.

1) Kyrgyz State Medical Academy named after I.K. Akhunbaev, Bishkek, Kyrgyzstan; 2) Salymbekov University, Bishkek, Kyrgyzstan; 3) Kyrgyz Research Institute of Animal Husbandry and Pastures, Bishkek, Kyrgyzstan; 4) Sechenov First Moscow State Medical University, Moscow, Russia; 5) Burdenko Main Military Clinical Hospital, Moscow, Russia; 6) Saint Petersburg State University, Saint Petersburg, Russia; 7) Kazan State Medical University, Kazan, Russia; 8) Osh State University, Osh, Kyrgyzstan; 9) Loginov Moscow Clinical Scientific and Practical Center, Moscow, Russia; 10) Green Clinic Medical Center, Bishkek, Kyrgyzstan

Background. Chronic kidney disease (CKD) is a widespread chronic non-infectious disease that represents a serious medical and social problem. One of the early laboratory manifestations of CKD is anemia, the incidence of which increases as renal dysfunction progresses. Nephrogenic anemia is considered as a factor contributing to the progression of CKD and the development of its complications. Objective. Assessment of the prevalence of anemia and its relationship with renal function parameters in patients with CKD. Material and methods. The study included 887 patients with CKD of various etiologies, including 419 men (mean age 47,5 years) and 468 women (mean age 52,4 years). All patients underwent a comprehensive clinical and laboratory examination with an assessment of red blood parameters and renal filtration rates. Results. Anemia was detected in 50,2% of patients with CKD at the pre- and predialysis stages. Its prevalence among women (51,9%) was slightly higher than among men (48,4%). The average levels of hemoglobin (Hb) and hematocrit (Ht) in men (125,5 g/L and 41,8%, respectively) were significantly higher than in women (111,7 g/L and 38,9%; p<0,05). Hypercholesterolemia was diagnosed more often in women (43,8%) than in men (36,0%). In men with CKD, a significant inverse correlation between the Hb (r=-0,542; p<0,001) and Ht (r=-0,547; p<0,001) concentration with the glomerular filtration rate (GFR), as well as the blood non-protein nitrogen (r=-0,434; p<0,005) and blood urea (r=-0,462; p<0,001) levels was found. In women, the Hb concentration also correlated with the GFR (r=-0.477; p<0.005), blood non-protein nitrogen (r=-0.525; p<0.001) and blood urea level (r=-0,528; p<0,001). In addition, a weak but statistically significant correlation of Hb concentration with total cholesterol level was found in women (r=-0,130; p<0,05), and the red blood cell count correlated with total cholesterol level (r=-0,118; p<0,05). Conclusion. Anemia occurs in 50.2% of patients with CKD and is an important predictor of chronic renal failure progression, especially in women.

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About the Authors

Ilkhom T. Murkamilov – Dr.Sci. (Med.), Corresponding Member of the Russian Academy of Natural Sciences, Associate Professor at the Department of Faculty Therapy, KSMA n.a. I.K. Akhunbaev, Director of the Multidisciplinary Medical Center «Doc University Clinic», Salymbekov University. Address: 92 Akhunbaev St., Bishkek, 720020;
Tel.: (+996) 557-221-983; E-mail: murkamilov.i@mail.ru. ORCID: https://orcid.org/0000-0001-8513-9279.
Kubanych A. Aitbaev – Dr.Sci. (Med.), Professor, Head of the Department of Pathological Physiology, Research Institute of Molecular Biology and Medicine.
Address: 3 T. Moldo st., Bishkek, 720040; tel.: (+996) 555-758-476; e-mail: aitbaev.kuban1940@gmail.com. ORCID: https://orcid.org/0000-0003-4973-039X.
Viktor V. Fomin – Dr.Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Faculty Therapy No. 1, N.V. Sklifosovsky Institute of Clinical Medicine, Vice-Rector for Innovation and Clinical Activities, Sechenov First Moscow State Medical University. Address:2 Bolshaya Pirogovskaya st.,
Moscow, 119991; tel.: 8 (495) 609-14-00, ext. 2142; e-mail: fomin_vic@mail.ru. ORCID: https://orcid.org/0000-0002-2682-4417.
Zafarbek R. Raimzhanov – Neurologist, 29th Neurological Department, N.N. Burdenko Main Military Clinical Hospital. Address: 3 Hospitalnaya square, Moscow, 105094;
tel.: 8 (499) 263-55-55; e-mail: rzrmam@mail.ru. ORCID: https://orcid.org/0000-0001-5746-6731.
Shavkat Sh. Khakimov – Head of the Department of Critical Care, Therapy and Diagnostics, Salymbekov University. Address: 144 Bokonbaev str., Bishkek, 720040;
tel.: (+996) 551-660-013; e-mail: hakimovshaki13@gmail.com. ORCID: https://orcid.org/0009-0004-0437-0188.
Gulzat K. Duysheeva – Teaching Assistant at the Department of Faculty Therapy, KSMA named after I.K. Akhunbaev. Address: 92 Akhunbaev st., Bishkek, 720020;
tel.: (+996) 770-252-528; e-mail: guzyu_88@mail.ru. ORCID: https://orcid.org/0000-0002-8847-5937.
Islombek U. Abdurakhmanov – Therapist, Researcher, City Polyclinic №120. Address: Bldg. 1, 4 Lenskaya st., St. Petersburg, 199034, St. Petersburg State University.
Address: bld. 8a 21st lin. V.O., St. Petersburg, 199106; tel.: +7 (952) 227-50-47; e-mail: ali_islam95@mail.ru. ORCID: https://orcid.org/0009-0006-0660-0113.
Zhaloliddin I. Solizhonov – 6th-year student at the Faculty of General Medicine, Kazan State Medical University. Address: 49 Butlerov st., Kazan, 4200;
tel.: (+495) 967-4690-0438; E-mail: jaloliddinsolijonov44@gmail.com. ORCID: https://orcid.org/0009-0003-0078-0609.
Yodgor R. Boymurodov – 4th year student at the Faculty of General Medicine, Kazan State Medical University. Address: 49 Butlerov st., Kazan, 420012;
tel.: (+495) 953-4944-852; E-mail: yodiboymurodov@gmail.com. ORCID: https://orcid.org/0009-0000-5966-1450.
Tursunoy F. Yusupova – Clinical Resident at the Department of Neurology, Neurosurgery and Psychiatry, Medical Faculty, Osh State University.
Address: 331 Lenin st., Osh, 723500; Tel.: (+996) 707-130-938; E-mail: yusupova_tursunoy_f@mail.ru. ORCID: https://orcid.org/0000-0002-8502-2203.
Zulhumor F. Yusupova – 4th year student at the Medical Faculty, Osh State University. Address: Address: 331 Lenin st., Osh, 723500; Tel.: (+996) 707-130-938;
E-mail: zulkhumor.yusupova.f_05@mail.ru. ORCID: https://orcid.org/0000-0001-7621-1128.
Furkat A. Yusupov – Dr.Sci. (Med.), Professor, Head of the Department of Neurology, N eurosurgery and Psychiatry, Faculty of Medicine, Osh State University.
Address: 331 Lenin st., Osh, 723500; Tel.: (+996) 990-999-291; E-mail: furcat_y@mail.ru. ORCID: https://orcid.org/0000-0003-0632-6653.
Ibadilla A. Abdibaliev – Researcher, Loginov Moscow Medical Scientific Center, Moscow Healthcare Department. Address: 86 Entuziastov Shosse, Moscow, 111123;
Tel.: +7 (926) 765-70-77.
Kamranbey A. Gasanov – Researcher, KSMA named after I.K. Akhunbaev. Address: 92 Akhunbaev st., Bishkek, 720020; tel.: (+996 ) 700-201-297;
e-mail: gassanov_k@mail.ru. ORCID: 0000-0003-0173-8851.
Komil K. Khabibullaev – 6th year student at the Faculty of Medicine, KSMA named after I.K. Akhunbaev. Address: 92 Akhunbaev st., Bishkek, 720020; tel.: (+996) 706-474-201; e-mail: khabibullaevkomil2001@gmail.com. ORCID: https://orcid.org/0009-0004-5508-8019.
Daniyar S. Ymankulov – Researcher, Plastic Surgeon, Green Clinic. Address: 118 Isanov str., Bishkek 720040; tel.: (+996) 551-196-991;
e-mail: ymankulov9595@mail.ru. ORCID: https://orcid.org/0009-0000-4975-1196.

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