Long-term results of hydroxychloroquine therapy in patients with immunoglobulin A nephropathy

Komissarov K.S., Krasko O.V., Pilotovich V.S.

1) Minsk Scientific and Practical Center for Surgery, Transplantology, and Hematology, Minsk, Republic of Belarus; 2) Belarusian State Medical University, Minsk, Republic of Belarus; 3) United Institute of Informatics Problems of the National Academy of Sciences of Belarus, Minsk, Republic of Belarus

Objective. Analysis of long-term outcomes after completing a 6-month course of hydroxychloroquine (HCQ) therapy in patients with immunoglobulin A nephropathy (IgAN).
Material and methods. Clinical and laboratory parameters and the remission rate were prospectively determined in 20 patients with IgAN after a course of HCQ therapy.
Results. The follow-up period ranged from 13 to 59 months (median 45 months). In the group of patients (n=14) who achieved clinical and laboratory remission after a course of hydroxychloroquine therary, sustained remission was observed in 8 (57.1%) patients. In cases of relapse, repeated administration of hydroxychloroquine promoted remission in 2 of 3 patients. No adverse effects of treatment were recorded.
Conclusion. Hydroxychloroquine can be used as an effective alternative therapy in patients with IgAN.

Keywords

About the Authors

Kirill S. Komissarov – Cand.Sci, (Med.), Associate Professor, Head of the Department of Nephrology, Renal Replacement Therapy and Kidney Transplantation, Minsk Scientific and Practical Center for Surgery, Transplantology, and Hematology. Address: 8 Semashko St., Minsk, Republic of Belarus, 220087; tel.: +37517 2 772035,
+375 29 6 807097; e-mail: kirill_ka@tut.by. ORCID: 0000-0002-2648-0642
Olga V. Krasko – Cand.Sci, (Tech.), Associate Professor, Leading Researcher, Bioinformatics Laboratory, Joint Institute for Informatics, National Academy of Sciences of Belarus. Address: 6 Surganov St., Minsk, Republic of Belarus, 220012; Email: olga.krasko.ok@gmail.com. ORCID: 0000-0002-4150-282X
Valery S. Pilotovich – Dr.Sci. (Med.), Professor, Department of Urology and Nephrology, Belarusian State Medical University. Address: 83 Dzerzhinsky Ave., Minsk, Republic of Belarus 220083; Tel.: +375 17 265-25-61; Email: pilotovich@mail.ru. ORCID: 0000-0001-8256-5889

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