Molecular and physiological bases of atrial fibrillation in chronic kidney disease

Igamberdieva R.Sh., Daminov B.T.

1) Tashkent State Medical University, Tashkent, Uzbekistan; 2) Republican Specialized Scientific and Practical Medical Center of Nephrology and Kidney Transplantation, Tashkent, Uzbekistan

Chronic kidney disease (CKD) is a progressive and most pressing problem of the healthcare system worldwide, since its prevalence reaches 15% among the world population. CKD increases mortality due to secondary complications, such as cardiovascular pathologies, including atrial fibrillation (AF). This review discusses well-known systemic factors linking CKD with pathogenetic and pathophysiological mechanisms of AF. The involvement of several inflammatory mediators in atrial arrhythmogenesis is emphasized, as well as the need for a deeper understanding of the molecular basis and high-quality clinical studies of the relationship between these comorbid conditions.

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About the Authors

Ranokhon Sh. Igamberdieva – Cand.Sci. (Med.), Teaching Assistant, Department of Internal Medicine, Nephrology and Hemodialysis, Tashkent State Medical University. Address: 223 Bogishamol st., Yunusabad district, Tashkent, Uzbekistan, 100140; tel.: +998 (97) 342-06-33; e-mail: ranokhon.igamberdieva82@gmail.com. ORCID: 0000-0002-7314-0309.
Botir T. Daminov – Dr.Sci. (Med.), Professor, Director of the Republican Specialized Scientific and Practical Medical Center of Nephrology and Kidney Transplantation; Professor at the Department of Internal Medicine, Nephrology and Hemodialysis, Tashkent State Medical University. Address: 223 Bogishamol st., Yunusabad district, Tashkent, Uzbekistan, 100140; tel.: +998 (90) 185-31-73; e-mail: daminovbotir@gmail.com. ORCID: 0000-0002-9149-0831.

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