Acute kidney injury in patients with COVID-19: severity of inflammatory response and risk of chronic kidney disease development
Objective. Evaluation of the functional state of the kidneys in patients with acute kidney injury (AKI) after COVID-19, one year or more after hospitalization.Mikhailova L.V., Perepelitsa S.A., Struchkov S.T., Orlova Yu.A., Akchurina K.N.
Material and methods: The analysis of data from 437 patients who had COVID-19 and were discharged from the hospital in 2021 and 2022 was performed. The creatinine, blood urea, CRP, ferritin, lactate dehydrogenase, interleukin-6 levels during hospitalization and the dynamics of creatinine, blood urea, estimated glomerular filtration rate a year or more after hospitalization and the presence of concomitant somatic diseases were assessed.
Results. At the time of hospitalization, 76 (20.5%) patients had signs of AKI. Patients with AKI were statistically significantly older, they were more likely to have arterial hypertension, coronary artery disease and diabetes mellitus, and they had higher levels of inflammatory markers during hospitalization. One year or more after hospitalization, creatinine and urea levels, as well as the number of patients with stage 3 chronic kidney disease, were higher among patients who had COVID-19 with AKI.
Keywords
COVID-19
acute kidney injury
chronic kidney disease
kidney damage
outpatient follow-up
About the Authors
Larisa V. Mikhailova – Cand.Sci. (Med.), Associate Professor, Head of the Therapy Department, Institute of Medicine and Life Sciences (MEDBIO), Immanuel Kant Baltic Federal University. Address: 4/6 Botkin St., Kaliningrad, Kaliningrad Region, 236016; tel.: 8 (962) 265-14-66; e-mail: mihalysa@mail.ru. ORCID: 0000-0001-5070-5955.Svetlana A. Perepelitsa – Dr.Sci. (Med.), Head of the Department of Surgical Disciplines, Institute of Medicine and Life Sciences (MEDBIO), Immanuel Kant Baltic Federal University. Address: Address: 4/6 Botkin St., Kaliningrad, Kaliningrad Region, 236016; Leading Researcher, Negovsky Research Institute of General Reanimatology, Federal Scientific and Clinical Center for Intebsive Care Medicine and Rehabilitology. Address: Bldg. 2, 25 Petrovka St., Moscow, 107031; tel.: 8 (906) 218-80-91;
e-mail: sveta_perepeliza@mail.ru. ORCID: 0000-0002-4535-9805.
Sergey T. Struchkov – 2nd year clinical resident physician, specialty “therapy”, Institute of Medicine and Life Sciences (MEDBIO), Immanuel Kant Baltic Federal University. Address: 4/6 Botkin St., Kaliningrad, Kaliningrad Region, 236016; tel.: 8 (984) 100-58-07; e-mail: sergey17011990@gmail.com. ORCID: 0009-0004-7886-3655.
Yulia A. Orlova – 6th year student, specialty 31.05.01 “General Medicine”, Institute of Medicine and Life Sciences (MEDBIO), Immanuel Kant Baltic Federal University.
Address: 4/6 Botkin St., Kaliningrad, Kaliningrad Region, 236016; tel.: 8 (962) 267-42-67; e-mail: yuliya_orlova2001@mail.ru. ORCID: 0009-0009-4880-145C.
Ksenia N. Akchurina – 6th year student, specialty 31.05.01 “General Medicine”, Institute of Medicine and Life Sciences (MEDBIO), Immanuel Kant Baltic Federal University. Address: 4/6 Botkin St., Kaliningrad, Kaliningrad Region, 2360166; tel.: 8 (911) 480-09-38; e-mail: ksyu.akchurina.01@mail.ru. ORCID: 0009-0000-4996-380X.
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