Relationship between nutritional insufficiency and progression of acute kidney injury in children with signs of multiple organ failure

Ashurova G.Z., Mamatkulov I.B.

1) Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan; 2) Tashkent State Medical University, Tashkent, Uzbekistan

Background. Acute kidney injury (AKI) remains one of the most common and severe forms of organ dysfunction in children in intensive care units. According to current data, the incidence of AKI in critically ill children reaches 30 to 50% and increases significantly in the presence of sepsis, systemic inflammatory response, multiple organ failure, and massive infusion therapy. Clinical and laboratory signs of AKI include a decrease in the rate of diuresis, an increase in creatinine levels, and disturbances in electrolyte and acid-base balances.
Objective. Assessment of the relationship between the nutritional deficiency and the progression of AKI in children in critical condition.
Material and methods. The study included 56 children with AKI, who were stratified into groups by the degree of protein-energy malnutrition. Anthropometric and laboratory parameters were assessed, including albumin and prealbumin levels, diuresis rate, and duration of renal dysfunction.
Results. A significant relationship between the severity of nutritional deficiency and the prolongation of the AKI period was established. Patients with severe protein-energy malnutrition had a significant decrease in protein markers, a longer course of oliguria, and an increased incidence of complications.
Conclusion. Nutritional deficiency has an adverse effect on the course of AKI in children. Protein metabolism markers can be used to assess prognosis and select treatment tactics in intensive care.

Keywords

About the Authors

Gulchekhra Z. Ashurova – Cand.Sci, (Med.), Teaching Assistant, Department of Anesthesiology and Resuscitation, Pediatric Anesthesiology and Resuscitation,
Tashkent State Medical University Address: Uzbekistan, 100109, Tashkent, Farabi St., 2; National Medical Children’s Center. Address: 294 Parkent street, Yashnabad district, Tashkent, Uzbekistan, 100207. e-mail: gulibaur@gmail.com. ORCID: 0000-0001-6437-8967, eLibrary SPIN: 7063-0126.
Ikhtiyor B. Mamatkulov – Cand.Sci, (Med.), Associate Professor, Department of Anesthesiology and Resuscitation, Pediatric Anesthesiology and Resuscitation, Tashkent
State Medical University Address: Uzbekistan, 100109, Tashkent, Farabi St., 2; e-mail: mikhtiyor77@mail.ru. ORCID: 0000-0003-4053-4544.

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