Acute kidney injury in diabetic patients: clinical course and prognosis

Murkamilov I.T., Aitbaev K.A., Fomin V.V., Raimzhanov Z.R., Yusupov F.A., Yusupova T.F., Yusupov A.F., Solizhonov Zh.I., Khabibullaev K.K.

1) Kyrgyz State Medical Academy named after I.K. Akhunbaev, Bishkek, Kyrgyzstan; 2) Salymbekov University, Bishkek, Kyrgyzstan; 3) Russian Medical Academy of Continuous Professional Education, Moscow, Russia; 4) N.N. Burdenko Main Military Clinical Hospital, Moscow, Russia; 5) Osh State University, Osh, Kyrgyzstan; 6) Republican Specialized Scientific and Practical Medical Center for Nephrology and Kidney Transplantation, Tashkent, Uzbekistan

Background. Currently, more than 537 million people worldwide suffer from type 2 diabetes mellitus (DM2), and this number is projected to increase to 783 million by 2045. Among the chronic DM2complications, diabetic microangiopathy and nephropathy occupy a special place. Albuminuria, podocinuria, and nephrinuria are considered early preclinical markers of kidney damage in DM2. Clinical forms of kidney damage in DM2 include acute kidney injury (AKI), acute kidney disease, chronic kidney disease (CKD), and others. Risk factors for the development of AKI in DM2 patients include advanced age, male gender, long-term disease, uncontrolled glycemic profile, arterial hypertension, short-term exposure to extreme heat, infectious and inflammatory processes, the presence of CKD, and others. The development of acute kidney injury (AKI) in DM2 worsens the long-term prognosis and increases the risk of in-hospital mortality.
Description of the clinical case. This article presents the results of a clinical folloew-up of patient R., 66, with AKI that developed against the background of type 2 diabetes mellitus. It is demonstrated that timely diagnosis and treatment of AKI can lead to a favorable outcome. During the patient’s follow-up, serum biomarkers—creatinine and cystatin C—were used to assess renal function.

Keywords

About the Authors

Ilkhom T. Murkamilov – Dr.Sci. (Med.), Corresponding Member of the Russian Academy of Natural Sciences, Associate Professor, Department of Faculty Therapy, Kyrgyz State Medical Academy named after. I.K. Akhunbaev, Director of the Multidisciplinary Medical Center “Doc University Clinic”, Salymbekov University.
Address: 92 Akhunbaev St., Bishkek, 720020; Tel.: (+996) 557-221-983; E-mail: murkamilov.i@mail.ru. ORCID: 0000-0001-8513-9279
Kubanich A. Aitbaev – Dr.Sci. (Med.), Professor, Consultant of the Department of Resuscitation, Therapy, and Diagnostics, Multidisciplinary Medical Center “Salymbekov University”. Address: 144 Bokonbaev St., Bishkek, 720040; Tel.: (+996) 555-758-476; E-mail: aitbaev.kuban1940@gmail.com. ORCID: 0000-0003-4973-039X
Viktor V. Fomin – Dr.Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Rector of the Russian Medical Academy of Continuous Professional Education. Address: Bldg. 1 2/1 Barrikadnaya St., Moscow, 125993; E-mail: fomin_vic@mail.ru. ORCID: 0000-0002-2682-4417
Zafarbek R. Raimzhanov – Neurologist, 29th Department of Neurology, N.N. Burdenko Main Military Clinical Hospital, Address: 3 Hospital Square, Moscow, 105094;
Tel.: +7 (499) 263-55-55; E-mail: rzrmam@mail.ru. ORCID: 0000-0001-5746-6731
Furkat A.Yusupov – Dr.Sci. (Med.), Professor, Head of the Department of Neurology, Neurosurgery, and Psychiatry, Faculty of Medicine, Osh State University.
Address: 331 Lenin St., Osh, 723500; Tel.: (+996) 990-999-291; E-mail: furcat_y@mail.ru. ORCID: 0000-0003-0632-6653
Tursunoy F. Yusupova – Clinical Resident, Department of Neurology, Neurosurgery, and Psychiatry, Faculty of Medicine, Osh State University.
Address: 331 Lenin St., Osh, 723500; Tel.: (+996) 707-130-938; Email: yusupova_tursunoy_f@mail.ru. ORCID: 0000-0002-8502-2203
Abdulkhokim F. Yusupov – Assistant Professor, Department of Neurology, Neurosurgery, and Psychiatry, Faculty of Medicine, Osh State University.
Address: 331 Lenin St., Osh, 723500; Tel.: (+996) 999-767-808; Email: furcat_y@mail.ru
Zhaloliddin I. Solizhonov – clinical resident at the Republican Specialized Scientific and Practical Medical Center for Nephrology and Kidney Transplantation. Address: 9 Yangi Shahar Street, Tashkent 100194; phone: (+495) 967-4690-0438; e-mail:jaloliddinsolijonov44@gmail.com. ORCID: 0009-0003-0078-0609
Komil K. Khabibullaev – Resident Doctor, Kyrgyz State Medical Academy named after. I.K. Akhunbaev. Address: 92 Akhunbaev St., Bishkek, 720020; Tel.: (+996) 706-474-201, E-mail: khabibullaevkomil2001@gmail.com. ORCID: 0009-0004-5508-8019

Similar Articles