Morphological structure of late kidney transplant dysfunction
Objective: to analyze the causes of late kidney allograft dysfunction according to results of kidney transplant histopathological examination performed from 2013 to 2022.Rapetskaya N.V., Komissarov K.S., Dmitrieva M.V., Liatkoyskaya T.A., Kalachyk A.V.
Material and methods. Analysis of late kidney allograft dysfunction causes was carried out according to 431 reports of kidney transplant biopsies performed in Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology, Republic of Belarus.
Results. The main causes of kidney transplant dysfunction in late posttransplant period were antibody-mediated rejection – 26.7%, recurrent or de novo glomerular diseases – 22.7%, chronic allograft nephropathy – 16%.
Keywords
kidney transplant dysfunction
kidney biopsy
transplant rejection
antibody-mediated rejection
kidney transplantation
About the Authors
Rapetskaya Nadzeya V. – Nephrologist, Department of Transplant Nephrology, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology.Address: Minsk, Semashko str., 8; tel.: +3 (7517) 390-84-81, +3 (7529) 787-82-56; e-mail: n.rapetskaja@gmail.com. ORCID: 0009-0005-4560-1162.
Komissarov Kirill S. – PhD (Med. Sci), Associate Professor, Head of the Department of Nephrology, Renal Replacement Therapy and Kidney Transplantation, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology. Address: Minsk, Semashko str., 8; tel.: +3 (7517) 277-20-35, +3 (7529) 680-70-97; e-mail: kirill_ka@tut.by. ORCID: 0000-0002-2648-0642.
Dmitrieva Margarita V. – PhD (Med. Sci), Associate Professor, Department of Pathological Anatomy and Forensic Medicine, Belarusian State Medical University.
Address: Minsk, Kizhevatova str., 60; tel.: +3 (7517) 277-13-19; e-mail: mvdmitieva@inbox.ru. ORCID: 0000-0002-2958-9424.
Liatkoyskaya Tatiana A. – PhD (Med. Sci), Associate Professor, Head of the Department of Pathological Anatomy and Forensic Medicine, Belarusian State Medical University. Address: Minsk, Kizhevatova str., 60; tel.: +3 (7517) 398-72-37; e-mail: taletkovskaya@mail.ru. ORCID: 0000-0002-9381-2985.
Kalachyk Aleh V. – DSc (Med. Sci), Professor, Deputy Director for Medical Affairs, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology.
Address: Minsk, Semashko str., 8; tel.: +3 (7517) 277-19-92; e-mail: oleg_kalachik@hotmaill.com. ORCID: 0009-0002-6954-675X.
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