Mesenchymal stem cells in the treatment of chronic active humoral rejection of renal transplant: a pilot study

Rapetskaya N.V., Komissarov K.S., Dmitrieva M.V., Nazarova E.A., Prymakova E.A., Dedyulya N.I., Symanovich A.A., Yurkina E.G., Romanova I.A., Krivenko S.I., Kalachyk O.V.

1) Minsk Scientific and Practical Center for Surgery, Transplantology, and Hematology, Minsk, Republic of Belarus; 2) Belarusian State Medical University, Minsk, Republic of Belarus

Objective. Evaluation of the safety and efficacy of mesenchymal stem cells (MSCs) in the treatment of chronic active humoral kidney graft rejection (CAHKGR).
Materials and methods. A pilot study was conducted using mesenchymal stem cells (MSCs) in the treatment of morphologically verified CAHKGR in 7 kidney recipients.
Results. No statistically significant changes in creatinine levels, glomerular filtration rate (GFR), or proteinuria were observed after MSC treatment. The one-year graft survival rate was 100%. No deaths or serious complications from MSC therapy were recorded.
Conclusion. The use of MSCs is a promising approach in transplant nephrology due to its positive effect on the renal allograft, including stabilization of GFR, satisfactory tolerability of therapy, and minimal complications, which allows for increased graft survival.

Keywords

About the Authors

Nadzeya V. Rapetskaya – Nephrologist, Department of Transplant Nephrology, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology.
Address: 8 Semashko St., Minsk; tel.: +3 (7517) 390-84-81, +3 (7529) 787-82-56; e-mail: n.rapetskaja@gmail.com. ORCID: 0009-0005-4560-1162.
Kirill S. Komissarov – Cand.Sci. (Med.), Associate Professor, Head of the Department of Nephrology, Renal Replacement Therapy and Kidney Transplantation, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology. Address: 8 Semashko St., Minsk; Tel.: +3 (7517) 277-20-35, +3 (7529) 680-70-97; e-mail: kirill_ka@tut.by. ORCID: 0000-0002-2648-0642.
Margarita V. Dmitrieva – Cand.Sci. (Med.), Associate Professor, Department of Pathological Anatomy, Belarusian State Medical University. Address: 60 Kizhevatov St., Minsk; Tel.: +3 (7517) 277-13-19; e-mail: mvdmitieva@inbox.ru. ORCID: 0000-0002-2958-9424.
Ekaterina A. Nazarova – Cand.Sci. (Biology), Associate Professor, Clinical Laboratory Diagnostics Doctor, Laboratory of Cellular Biotechnology, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology. Address: 8 Semashko St., Minsk; Tel.: +3 (7517) 277-30-43; e-mail: k.nazarova-86@mail.ru. ORCID: 0000-0001-7147-4834.
Evgeniya A. Prymakova – Clinical Laboratory Diagnostics Doctor, Laboratory of Cellular Biotechnology, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology. Address: 8 Semashko St., Minsk; Tel.: +3 (7517) 277-30-43; e-mail: gane_sel@mail.ru. ORCID: 0000-0002-3011-2287.
Natalya I. Dedyulya – Cand.Sci. (Biology), Associate Professor, Head of the Laboratory of Cellular Biotechnology, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology. Address: 8 Semashko St., Minsk; Tel.: +3 (7517) 277-30-43; E-mail: nata_2010@tut.by. ORCID: 0000-0001-9807-2093.
Alla A. Symanovich – Cand.Sci. (Biology), Clinical Laboratory Diagnostics Doctor, Laboratory of Cellular Biotechnology, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology. Address: 8 Semashko St., Minsk; Tel.: +3 (7517) 277-30-43; e-mail: aleftyna@tut.by. ORCID: 0000-0003-1521-1620.
Ekaterina G. Yurkina – Senior Researcher, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology. Address: 8 Semashko St., Minsk;
Tel.: +3 (7517) 277-07-63; e-mail: ekatherina999@mail.ru. ORCID: 0000-0002-0966-7456.
Irina A. Romanova – Researcher, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology. Address: 8 Semashko St., Minsk;
Tel.: +3 (7517) 277-07-63; e-mail: romirina1978@gmail.com. ORCID: 0000-0001-6577-9738.
Svetlana I. Krivenko – Dr.Sci. (Med.), Professor, Deputy Director for Research, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology.
Address: 8 Semashko St., Minsk; Tel.: +3 (7517) 277-07-63; e-mail: svtl_kr@tut.by. ORCID: 0000-0002-6813-4465.
Aleh V. Kalachyk – Dr.Sci. (Med.), Professor, Deputy Director for Medical Affairs, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology.
Address: 8 Semashko St., Minsk; tel.: +3 (7517) 277-19-92; e-mail: oleg_kalachik@hotmaill.com. ORCID: 0009-0002-6954-675X.

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