Phase angle as an early marker of sarcopenia development

Sokolova A.V., Dragunov D.O., Arutyunov G.P., Toporkova E.V., Suleimanova D.R., Abdusalyamova S.R., Skripachuk D.I.

1) Pirogov Russian National Research Medical University, Moscow, Russia; 2) Research Institute for Healthcare Organization and Medical Management, Moscow Healthcare Department, Moscow, Russia

Objective. Evaluation of the relationship between phase angle (PA) and sarcopenia indicators in patients with chronic heart failure (CHF) and chronic kidney disease (CKD). Materials and methods. The study included 144 patients with CHF and CKD, of whom 46 (32%) had no signs of sarcopenia (Group 1), 62 (43%) were diagnosed with presarcopenia (Group 2), and 36 (25%) with established sarcopenia (Group 3). In the overall sample, the mean age was 68.04±9.72 years. Results. The PA significantly differed between the groups: the median PA increased from the non-sarcopenic to the sarcopenic group (p=0.0017), with pairwise differences between groups 1–3 (p=0.0007) and 2–3 (p=0.024), and a trend between 1–2 (p=0.059). Correlation analysis revealed associations between muscle status and nutritional and renal parameters: skeletal muscle mass correlated with albumin (p=0.61; p=0.015) and creatinine (p=0.29; p=0.004), PA - with glomerular filtration rate (GFR) (p=0.38; p=0.00016), and shoulder muscle area with GFR (p=0.43; p=0.0006) and C-reactive protein (p=-0.62; p=0.002), indicating a link between deteriorating kidney function and inflammation with muscle degradation and the severity of sarcopenia. Conclusion. PA significantly differs in patients with CHF and CKD depending on sarcopenic status (p<0.001). PA can be considered as a promising indicator for early screening and risk stratification of sarcopenia.

Keywords

About the Authors

Grigory P. Arutyunov – Dr.Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Propaedeutics of Internal Medicine No. 1, Institute of Clinical Medicine, Pirogov Russian National Research Medical University (Pirogov University). Address: 1 Ostrovityanova St., Moscow, 117513; e-mail: arut@ossn.ru. ORCID: 0000-0002-6645-2515
Dmitry O. Dragunov – Cand.Sci. (Med.), Associate Professor at the Department of Propaedeutics of Internal Medicine No. 1, Institute of Clinical Medicine, Pirogov Russian National Research Medical University (Pirogov University). Address: 1 Ostrovityanova St., Moscow, 117513, Head of the Organizational and Methodological Department for Therapy, Research Institute of Healthcare and Medical Sciences, Moscow Healthcare Department. Address: 9 Sharikopodshipnikovskaya St., Moscow, 115088; Tel.: +7 (910) 463-40-39; E-mail: tamops2211@gmail.com. ORCID: 0000-0003-1059-8387
Anna V. Sokolova – Cand.Sci. (Med.), Associate Professor at the Department of Propaedeutics of Internal Medicine No. 1, Institute of Clinical Medicine,, Pirogov Russian National Research Medical University (Pirogov University). Address: 1 Ostrovityanova St., Moscow, 117513; Leading Specialist, Organizational and Methodological Department for Therapy, Research Institute of Healthcare and Medical Sciences, Moscow Healthcare Department. Address: 9 Sharikopodshipnikovskaya St., Moscow, 115088; e-mail: Sokolova2211@gmail.com. ORCID: 0000-0003-0823-9190
Ekaterina V. Toporkova – 2nd-year Resident, Department of Propaedeutics of Internal Medicine No. 1, Institute of Clinical Medicine,, Pirogov Russian National Research Medical University (Pirogov University). Address: 1 Ostrovityanova St., Moscow, 117513; e-mail: katemmiracle@yandex.ru. ORCID: 0009-0009-9152-1920
Dzhamilya R. Suleymanova – 1st-year Resident, Department of Propaedeutics of Internal Medicine No. 1, Institute of Clinical Medicine,, Pirogov Russian National Research Medical University (Pirogov University). Address: 1 Ostrovityanova St., Moscow, 117513; e-mail: jamilyasr2003@mail.ru. ORCID: 0009-0009-0293-7394
Sabo R. Abdusalyamova – 6th year Student, Institute of Clinical Medicine, Pirogov Russian National Research Medical University (Pirogov University). Address: 1 Ostrovityanova St., Moscow, 117513; e-mail: sabo-02@mail.ru. ORCID: 0009-0005-5388-9848
Skripachuk Daria Igorevna – 6th year Student, Institute of Clinical Medicine, Pirogov Russian National Research Medical University (Pirogov University). Address: 1 Ostrovityanova St., Moscow, 117513; e-mail: dhvnldhvnl@gmail.com. ORCID: 0009-0006-8745-4989

Similar Articles