Use of tocilizumab in treatment of chronic active antibody mediated kidney transplant rejection

Rapetskaya N.V., Komissarov K.S., Dmitrieva M.V., Liatkoyskaya T.A., Kalachyk A.V.

1) Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology, Minsk, Republic of Belarus; 2) Belarusian State Medical University, Minsk, Republic of Belarus

Objective: to evaluate the safety and efficacy of tocilizumab in the treatment of chronic active antibody-mediated kidney transplant rejection.
Material and methods: A prospective study of tocilizumab use in the treatment of morphologically verified chronic active antibody-mediated transplant rejection was conducted in 15 kidney recipients.
Results and conclusion: in recipients who lost their graft function during the observation period, a high chronicity index was found according to morphological examination of the graft. After administration of tocilizumab, a decrease in the level of microvascular inflammation was observed.

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About the Authors

Nadzeya V. Rapetskaya – Nephrologist, Department of Transplant Nephrology, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology.
Address: Minsk, Belarus, Semashko str, 8, e-mail: n.rapetskaja@gmail.com, ORCID: 0009-0005-4560-1162
Kirill S. Komissarov – PhD (Med. Sci), Associate Professor, Head of the Department of Nephrology, Renal Replacement Therapy and Kidney Transplantation, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology. Address: Minsk, Belarus, Semashko str, 8, e-mail: kirill_ka@tut.by, ORCID: 0000-0002-2648-0642
Margarita V. Dmitrieva – PhD (Med. Sci), Associate Professor, Department of Pathological Anatomy and Forensic Medicine, Belarusian State Medical University.
Address: Minsk, Belarus, Kizhevatova str, 60, e-mail: mvdmitieva@inbox.ru, ORCID: 0000-0002-2958-9424
Tatiana A. Liatkoyskaya – PhD (Med. Sci), Associate Professor, Head of the Department of Pathological Anatomy and Forensic Medicine, Belarusian State Medical University. Address: Minsk, Belarus, Kizhevatova str, 60, e-mail: taletkovskaya@mail.ru, ORCID: 0000-0002-9381-2985
Aleh V. Kalachyk – DSc (Med Sci), Professor, Deputy Director for Medical Affairs, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology.
Address: Minsk, Belarus, Semashko str, 8, e-mail: oleg_kalachik@hotmaill.com, ORCID: 0009-0002-6954-675X

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