Clinical digitalization of the ultrastructural state of the podocyte in the process of infectious nephropathy implementation (pilot study)

Berdichevsky B.A., Vasilkova T.N., Zubik G.V., Uchaev D.A., Grimak E.S., Egorova A.A., Biybulatova. M.K.

1) Tyumen State Medical University, Tyumen, Russia; 2) Radiology Center, Tyumen Regional Clinical Medical Center «Medical City», Tyumen, Russia; 3) Research and Educational Center «Nanotechnology», South Ural State University, National Research Universityб Chelyabinsk, Russia

Objective. Evaluation of the feasibility of clinical digitalization of podocyte ultrastructural state using positron emission tomography/computed tomography (PET/CT) indicator of standardized 18F-FDG uptake by renal parenchymal and transmission electron microscopy data in a case of infectious tubulointerstitial nephritis.
Materials and methods. A pilot study of digital analysis of renal 18F-FDG PET/CT scans and podocyte ultrastructural assessment using transmission electron microscopy at 10,000x magnification was conducted.
Results. A pilot study demonstrated that digital PET/CT imaging of the standardized 18F-FDG uptake value (SUVmax) by renal parenchyma correlated with laboratory manifestations of infectious nephropathy and the main dimensional characteristics of the podocyte body, which correlated with its visual ultrastructural changes.
Conclusion. The feasibility of clinical digitalization of nephropathies is demonstrated using infectious tubulointerstitial nephritis as an example.

Keywords

About the Authors

Boris A. Berdichevsky – Dr.Sci. (Med.), Professor, Department of Pediatric Surgery with a Course in Urology and Andrology, Tyumen State Medical University, Tyumen;
e-mail: doktor_bba@mail.ru. ORCID: 0000-0002-9414-8510
Tatyana N. Vasilkova – Dr.Sci. (Med.), Professor, Chief External Expert in Therapy of the Ural Federal District, Head of the Department of Faculty Therapy, Tyumen State Medical University, Tyumen; e-mail: vasilkova@tyumsmu.ru. ORCID: 0000-0003-4753-6630
Grigory V. Zubik – Research Intern, Institute of Clinical Medicine, Tyumen State Medical University, Tyumen; e-mail: grisha.zubik@mail.ru. ORCID: 0009-0005-1333-2922
Daniil A. Uchaev – Leading Researcher, Department of Electron Microscopy and X-ray Analysis Methods, Research and Education Center «Nanotechnology», South Ural State University, National Research University, Tyumen; e-mail: uchaevda@susu.ru. ORCID: 0000-0002-8623-4769
Elizaveta S. Grimak – Student, Institute of Clinical Medicine, Tyumen State Medical University; E-mail: liza.grimak@mail.ru. ORCID: 0009-0006-1240-1620
Aleksandra A. Egorova – Student, Institute of Clinical Medicine, Tyumen State Medical University, Tyumen; E-mail: ealexandraa12@mail.ru. ORCID: 0009-0005-2234-9662
Malvina K. Biybulatova – Student, Institute of Clinical Medicine, Tyumen State Medical University, Tyumen; E-mail: malvina.biybulatova@mail.ru. ORCID: 0009-0002-7420-0702

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