Anti-phospholipase 2a receptor-associated membranous nephropathy in HIV-infected patients

Frolova N.F., Volgina G.V., Artyukhina L.Yu., Usatyuk S.S., Gadzhikulieva M.M., Tsyganova E.V., Dyakova E.N., Sysoeva I.L., Chernysheva O.O., Shakhnamazova R.A.

1) Moscow City Scientific and Practical Center of Nephrology and Transplanted Kidney Pathology, City Clinical Hospital No. 52 of the Moscow Healthcare Department, Moscow, Russia; 2) Russian University of Medicine, Moscow, Russia; 3) Moscow AIDS Prevention and Control Center of the Moscow Healthcare Department, Moscow, Russia

Anti-phospholipase A2 receptor (PLA2R)-associated membranous nephropathy (MN) is extremely rare in HIV-infected patients without known co-infections and poses significant challenges in terms of management and therapeutic choice. This article presents current aspects of MN and personal experience with the treatment of MN with positive PLA2R antibodies, confirmed by kidney biopsy, in HIV-infected patients. Treatment of idiopathic membranous nephropathy with glucocorticosteroids in combination with anti-CD20+ monoclonal antibodies (rituximab) against the background of normalization of the immune status due to antiretroviral therapy has resulted in remission of nephrotic syndrome without complications associated with the use of immunosuppressive drugs. Our experience confirms the effectiveness of this therapeutic approach.

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About the Authors

Nadiya F. Frolova – Cand.Sci. (Med.), Deputy Chief Physician for Nephrology Care, City Clinical Hospital No. 52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya St., Moscow, 123182; e-mail: nadiya.frolova@yandex.ru. ORCID: 0000-0002-6086-5220
Galina V. Volgina – Dr.Sci. (Med.), Professor, Department of Nephrology, N.A. Semashko Higher School of Clinical Medicine, Russian University of Medicine. Address: 4 Dolgorukovskaya St., Moscow, 127006; e-mail: volginagv@mail.ru. ORCID: 0000-0002-7771-4074
Lyudmila Yu. Artyukhina – Head of the Nephrology Department No.1, City Clinical Hospital No. 52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya St., Moscow, 123182; e-mail: arlyu-1404@yandex.ru. ORCID: 0000-0003-3353-1636
Sergey S. Usatyuk – Head of the Nephrology Department No.2, City Clinical Hospital No.52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya St., Moscow, 123182; e-mail: usatuk-doc@mail.ru. ORCID: 0000-0002-8742-3860
Madina M. Gadzhikulieva – Dr.Sci. (Med.), Professor, Department of Infectious Diseases and Epidemiology, N.A. Semashko Higher School of Clinical Medicine, Russian University of Medicine. Address: 4 Dolgorukovskaya St., Moscow, 127006; e-mail: madina67@mail.ru. ORCID: 0000-0002-0510-5050
Elena V. Tsyganova – Cand.Sci. (Med.), Infectious Disease Specialist, Head of the Scientific and Clinical Department, Moscow AIDS Prevention and Control Center of the Moscow Healthcare Department. Address: 15 8th Sokolinoy Gory St., Moscow, 105275; E-mail: TsyganovaElena@yandex.ru. ORCID: 0000-0002-3410-2510
Ekaterina N. Diakova – Nephrologist, Department of Nephrology No. 2, City Clinical Hospital No. 52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya St., Moscow, 123182; E-mail: Katerina-diakova@mail.ru. ORCID: 0000-0003-1599-1639
Irina L. Sysoeva – Nephrologist, Department of Nephrology No. 2, City Clinical Hospital No. 52 of the Moscow Healthcare Department. Address: 3 Pekhotnaya St., Moscow, 123182; E-mail: i.l.sysoeva@mail.ru. ORCID: 0000-0002-1904-9846
Olga O. Chernysheva – Resident Physician, Department of Infectious Diseases and Epidemiology, N.A. Semashko Higher School of Clinical Medicine, Russian University of Medicine. Address: 4 Dolgorukovskaya St., Moscow, 127006; e-mail: chernishevaoo@mail.ru. ORCID: https://orcid.org/0000-0003-4712-1240
Renata A. Shakhnamasova – Nephrologist, Nephrology Department No. 2, City Clinical Hospital No. 52, Moscow Healthcare Department. Address: 3 Pekhotnaya St., Moscow, 123182; e-mail: renata.sek.93@gmail.com. ORCID: 0009-0002-7148-7429

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