Prediction of urolithiasis development in patients on statin therapy taking into account genetic polymorphisms

Kovalenko A.V., Nikitina V.V.

Department of Biochemistry and Clinical Laboratory Diagnostics, Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia

Background. With prolonged use of statins, some patients experience the development of side effects. Damage to organs and systems can be caused by both the direct toxic effect of statin therapy and mediated through immunopathological reactions of the body. Researchers around the world are most interested in the association of urolithiasis with different alleles of genes involved in the regulation of vitamin D metabolism.
Description of the clinical case. The article describes a clinical case of determining the genetic polymorphism 283 A> G (BsmI) of the VDR gene in a patient with urolithiasis during statin therapy. The expected results of using the laboratory test – an increase in the efficiency of using immunogenetic predisposition for the early diagnosis of statin-induced urolithiasis.

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About the Authors

Alena V. Kovalenko – Senior Lecturer, Department of Biochemistry and Clinical Laboratory Diagnostics, Saratov State Medical University named after V.I. Razumovsky.
Address: 155 Moskovskaya st., Saratov, Russia, 410012; e-mail: alena.kovalenko@mail.ru. ORCID: 0000-0003-4535-3793
Viktoria V. Nikitina – PhD, Associate Professor, Department of Biochemistry and Clinical Laboratory Diagnostics, Saratov State Medical University named after V.I. Razumovsky. Address: 155 Moskovskaya st., Saratov, Russia, 410012; e-mail: vik-nik72@mail.ru. ORCID ID: 0000-0002-8893-8612

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